ID 21-127

Registered: 2009.09.10   Last update: 2020.11.24
Gene Name leucine-rich repeat-containing G protein-coupled receptor 4 Gene Symbol Lgr4
Chromosome 2 Genomic Location chr2:109,757,000-109,856,000
Synonyms Gpr48, A330106J01Rik, A930009A08Rik
Links UCSC Genome Browser(chr2:109,757,000-109,856,000)
NCBI Gene(107515)
IGTC(Lgr4,713)
UNIGene(Mm.277351)
 MGI(1891468)
KEGG GENES(mmu:107515)
EST Profile(mm.277351)
Other Clone Trapped This Gene
Trap Vector pU-21 Cell Line KTPU10 Method 5'-RACE
Accession AB520833 GSS Location chr2:109,758,373-109,824,823 Size 333
Sequence CTGCAGTGCGACGGCGACCGTCGGGGGACTGCTCCGGGAAGGGGTTGACGGCGGTACCGGAGGGG
CTCAGCGCCTTCACCCAAGCACTGGATATCAGTATGAACAATATCACTCAGTTACCAGAAGATGC
ATTTAAGAATTTTCCTTTTCTAGAGGAGCTCTCCCTCACAGTGTTTAAGTAGGCTGAGGCAGAAG
TCTTCTGGAGGTTCGTGGGAGTAGTCCAGGTGACTAATGGAGGATAAACTCATACCACAGAAAGA
CGATGACGACGAGCTCACGGCTTGGAATCTTGTAGAGTAATTTTCACCATCTTGGGAGCCAGAAG
CTACTGAG
Links UCSC Browser(chr2:109,758,373-109,824,823)
IGTC(Ayu21-127)

Homology Search Results

[NM_172671] Mus musculus leucine-rich repeat-containing G protein-coupled receptor 4 (Lgr4), mRNA.

Mouse Information

Card ID 1244
Strain Name B6;CB-Lgr4Gt(pU-21)127Card
Internal Code Ayu21-127
Description This clone was isolated by using the exchangeable gene trap vector;pU-21, and feeder free ES cell line; KTPU10 (F1 of B6 and CBA). Mouse line has been established from this clone, and deposited to the CARD R-BASE.
[Paper] "LGR4 regulates the postnatal development and integrity of male reproductive tracts in mice", Hoshii, T., Takeo, T., Nakagata, N., Takeya, M., Araki, K. and Yamamura, K., Biol. Reprod., 76, 303-313 (2007). PubMed ID:17079737.
[Paper] "Defective development of the gall bladder and cystic duct in Lgr4- hypomorphic mice", Ryo Yamashita, Yumiko Takegawa, Machiko Sakumoto, Mari Nakahara, Haruna Kawazu, Takayuki Hoshii, Kimi Araki, Yuji Yokouchi, and Ken-ichi Yamamura, Developmental Dynamics, 238, 993-1000 (2009). PubMed ID:19301403.
[Paper] "The lysophospholipase D enzyme Gdpd3 is required to maintain chronic myelogenous leukaemia stem cells.", Naka, K., Ochiai, R., Matsubara, E., Kondo, C., Yang, K. M., Hoshii, T., Araki, M., Araki, K., Sotomaru, Y., Sasaki, K., Mitani, K., Kim, D. W., Ooshima, A., Kim, S. J., Nat Commun,11,4681(2020). DOI: 10.1038/s41467-020-18491-9. PubMed ID:32943626.
Links IMSR (for Lgr4)