#(Publication/Ayu21-B171) "Tdrd3-null mice show post-transcriptional and behavioral impairments
associated with neurogenesis and synaptic plasticity." Zhu, X. et al., Progress in Neurobiology, 233,102568(2024). doi: 10.1016/j.pneurobio.2024.102568.PubMed ID: 38216113.
#(Publication/Ayu21-T278) "Tmem161a regulates bone formation and bone strength through the P38 MAPK pathway." Nagai, T. et al., Sci Rep, 13(1),14639(2023). doi: 10.1038/s41598-023-41837-4.PubMed ID: 37670024.
#(Publication/Ayu21-KBW111) "A gain-of-function mutation in microRNA 142 is sufficient to cause the development of T-cell leukemia in mice." Kawano, S. et al., Cancer Science, 114(7),2821-2834(2023). DOI:10.1111/cas.15794.PubMed ID: 36945113.
#(Publication/Ayu21-KBW122) "EPLINβ Is Involved in the Assembly of Cadherin-catenin Complexes in Osteoblasts and Affects Bone Formation." Miyazaki, S. et al., Acta Histochem. Cytochem.,55,99-110(2022). DOI:10.1267/ahc.22-00027.PubMed ID: 35821749.
#(Publication/Ayu21-B186) "LincRNA-p21 exon 1 expression correlates with Cdkn1a expression in vivo." Furuhata, R. et al., Genes to Cells,27,14-24(2022). DOI:10.1111/gtc.12906.PubMed ID: 34808017.
#(Publication/EGTC Database) "Gene trapping reveals a new transcriptionally active genome element: The chromosome‐specific clustered trap region." Takeda, I. et al., Genes to Cells,26,874-890(2021). DOI:10.1111/gtc.12890.PubMed ID: 34418226.
#(Publication/Ayu21-KBW111) "MicroRNA-142 Critically Regulates Group 2 Innate Lymphoid Cell Homeostasis and Function." Roberts, L. B. et al., J. Immunol.,206,2725-2739(2021). doi:10.4049/jimmunol.2000647. PubMed ID: 34021046.
#(Publication/Ayu21-T167) "The lncRNA Caren antagonizes heart failure by inactivating DNA damage response and activating mitochondrial biogenesis." Sato, M. et al., Nat Commun,12,2529(2021). doi:10.1038/s41467-021-22735-7. PubMed ID: 33953175.
#(Publication/EGTC database) "Tamoxifen feeding method is suitable for efficient conditional knockout." Yoshinobu, K., et al., Exp Anim,70(1),91-100(2021). doi: 10.1538/expanim.19-0138. PubMed ID: 33055491.
#(Publication/Ayu21-KBW111) "Mir142 loss unlocks IDH2(R140)-dependent leukemogenesis through antagonistic regulation of HOX genes." Marshall, A. et al., Sci Rep,10,19390(2020). doi: 10.1038/s41598-020-76218-8. PubMed ID: 33173219.
#(Publication/Ayu21-127) "The lysophospholipase D enzyme Gdpd3 is required to maintain chronic myelogenous leukaemia stem cells." Naka, K., et al., Nat Commun,11,4681(2020). doi: 10.1038/s41467-020-18491-9. PubMed ID: 32943626.
#(Publication/Ayu21-KBW111) "Identification and functional analysis of inflammation-related miRNAs in skin wound repair." Mori, R., et al., Dev. Growth Differ., 60, 306 (2018). doi: 10.1111/dgd.12542. Epub 2018 Jun 5. PubMed ID: 29873073.
#(Publication/Ayu21-B206) "LPA5 signaling is involved in multiple sclerosis-mediated neuropathic pain in the cuprizone mouse model." Tsukahara, R., et al., J. Pharmacol. Sci., 136, 93-96 (2018). pii: S1347-8613(18)30004-5. doi: 10.1016/j.jphs.2018.01.001. PubMed ID: 29409686.
#(Publication/Ayu21-KBW205) "WDR11-mediated Hedgehog signalling defects underlie a new ciliopathy related to Kallmann syndrome." Kim, Y-J., et al., EMBO reports, 19, 269-289 (2018). doi: 10.15252/embr.201744632. PubMed ID: 29263200. ***This paper was chosen as the cover story.***
#(Publication/Ayu21-B6T44) "Endothelial CD99 supports arrest of mouse neutrophils in venules and binds to neutrophil PILRs." Goswami, D., et al., Blood, 129(13),1811-1822 (2017). doi: 10.1182/blood-2016-08-733394. PubMed ID: 28223280.
#(Publication/EGTC database) "Development of an efficient screening system to identify novel bone metabolism-related genes using the exchangeable gene trap mutagenesis mouse models."Syuji Kurogi, et al., Sci. Rep., 7, 40692 (2017). doi: 10.1038/srep40692. PubMed ID: 28106071.
#(Publication/Ayu21-KBW111) "MiR-142 is required for Staphylococcus aureus clearance at skin wound sites via small GTPase-mediated regulation of the neutrophil actin cytoskeleton." Tanaka, K., et al., J. Invest. Dermatol., 137(4), 931-940 (2017). pii: S0022-202X(16)32664-1. doi: 10.1016/j.jid.2016.11.018. Epub 2016 Nov 25. PubMed ID: 27894934.
#(Publication/Ayu21-T2) "Image-based detection and targeting of therapy resistance in pancreatic adenocarcinoma." Fox, R.G., et al., Nature,534,407-411(2016). doi: 10.1038/nature17988. PubMed ID: 27281208.
#(Publication/Ayu21-KBW131) "Two transgenic mouse models for beta subunit components of succinate-CoA ligase yielding pleiotropic metabolic alterations." Kacso, G., et al., Biochemical Journal, 473(20), 3463-3485 (2016). Epub 2016 Aug 5. pii: BCJ20160594. doi: 10.1042/BCJ20160594. PubMed ID: 27496549.
#(Publication/Ayu21-18) "The importance of basonuclin 2 in adult mice and its relation to basonuclin 1." Vanhoutteghem, A., et al., Mechanisms of Development, 140,53-73 (2016). doi: 10.1016/j.mod.2016.02.002. Epub 2016 Mar 2. PubMed ID: 26923665.
#(Publication/Ayu21-81) "Pathophysiological significance of the two-pore domain K(+) channel K2P5.1 in splenic CD4(+)CD25(-) T cell subset from a chemically-induced murine inflammatory bowel disease model." S. Nakakura, et al., Frontiers in Physiology, 6, 299 (2015). doi: 10.3389/fphys.2015.00299. PubMed ID:26578971.
#(Publication/Ayu21-18) "The zinc-finger protein basonuclin 2 is required for proper mitotic arrest, prevention of premature meiotic initiation and meiotic progression in mouse male germ cells." Vanhoutteghem, A., et al., Development, 141, 4298-4310 (2014). doi: 10.1242/dev.112888. PubMed ID: 25344072.
#(Publication/Ayu21-B205) "Disruption of Mbd5 in mice causes neuronal functional deficits and neurobehavioral abnormalities consistent with 2q23.1 microdeletion syndrome." Camarena, V., et al., EMBO Molecular Medicine, 6, 1003-1015 (2014). doi: 10.15252/emmm.201404044. PubMed ID: 25001218.
#(Publication/Ayu21-W143) "NRBF2 regulates autophagy and prevents liver injury by modulating Atg14L-linked phosphatidylinositol-3 kinase III activity. " Jiahong Lu, et al., Nat. Commun., 5, 3920 (2014). doi: 10.1038/ncomms4920. PubMed ID: 24849286.
#(Publication/Ayu21-W371) "Conformational Change in Transfer RNA Is an Early Indicator of Acute Cellular Damage. " Eikan Mishima, et al., J. Am. Soc. Nephrology, 25 (10), 2316-2326 (2014). doi: 10.1681/ASN.2013091001. PubMed ID: 24833129.
#(Publication/Ayu21-T160) "The intramembrane proteases Signal-peptide-peptidase-like 2a and b (SPPL2a/b) have distinct functions in vivo. " Janna Schneppenheim, et al., Mol. Cell. Biol., 34 (8), 1398-1411 (2014). doi: 10.1128/MCB.00038-14. PubMed ID: 24492962.
#(Publication/EGTC database) "Database for exchangeable gene trap clones: Pathway and gene ontology analysis of exchangeable gene trap clone mouse lines."Masatake Araki, et al., Dev. Growth Differ., 56 (2), 161-174 (2014). doi: 10.1111/dgd.12116. PubMed ID: 24444128.
#(Publication/Ayu21-B6T44) "Interaction of CD99 with its paralog CD99L2 positively regulates CD99L2 trafficking to cell surfaces." Giri Nam, et al., J. Immunology, 191 (11), 5730-5742 (2013). doi: 10.4049/jimmunol.1203062. PubMed ID: 24133166.
#(Publication/Ayu21-81) "TASK-2: a K2P K(+) channel with complex regulation and diverse physiological functions." L. Pablo Cid, et al., Frontiers in Physiology, 4, 198 (2013). doi: 10.3389/fphys.2013.00198. PubMed ID: 23908634.
#(Publication/Ayu21-T346) "HOT1 is a mammalian direct telomere repeat-binding protein contributing to telomerase recruitment." Dennis Kappei, et al., EMBO J., 32 (12), 1681-1701 (2013). doi: 10.1038/emboj.2013.105. PubMed ID: 23685356.
#(Publication/Ayu21-MT1 ~ Ayu21-MT142) "Gene-trap mutagenesis using Mol/MSM-1 embryonic stem cells from MSM/Ms mice." Mai Nakahara, et al., Mamm. Genome, 24 (5-6), 228-239 (2013). doi: 10.1007/s00335-013-9452-4. PubMed ID: 23604909.
#(Publication/Ayu21-B6T44) "CD99-Dependent Expansion of Myeloid-Derived Suppressor Cells and Attenuation of Graft-Versus-Host Disease." Hyo Jin Park, et al., Molecules and Cells,33, 259-267 (2012). doi: 10.1007/s10059-012-2227-z. PubMed ID: 22350746.
#(Publication/AyuK14G12-AyuK17C03) "A homozygous mutant embryonic stem cell bank applicable for phenotype-driven genetic screening." K. Horie, et al., Nature Methods, 8, 1071-1077 (2011). doi: 10.1038/NMETH.1739. PubMed ID: 22020066.
#(Publication/Ayu21-18) "Human balanced translocation and mouse gene inactivation implicate Basonuclin 2 in distal urethral development." Elizabeth J Bhoj, et al., European Journal of Human Genetics, 19, 540-546 (2011). doi: 10.1038/ejhg.2010.245. PubMed ID: 21368915.
#(Publication/Ayu21-W34) "IGSF4 is a novel TCR zeta-chain-interacting protein that enhances TCR-mediated signaling." Hye-Ran Kim, et al., J. Exp. Med., 208, 2545-2560 (2011). doi: 10.1084/jem.20110853. PubMed ID: 22084409.
#EGTC server has been transferred to cloud computing . (2011.05.20)
#Search Function version up. (2011.04.27)
#(Publication/Ayu21-T93) "NSrp70 is a novel nuclear speckle-related protein that modulates alternative pre-mRNA splicing in vivo." Y. D. Kim, et al., Nuc. Acids Res., 39, 4300-4314 (2011). doi: 10.1093/nar/gkq1267. PubMed ID: 21296756.
#(Publication/Ayu21-T2) "Regulation of myeloid leukaemia by the cell-fate determinant Musashi." T. Ito, et al., Nature, 466, 765-768 (2010). doi: 10.1038/nature09171. PubMed ID: 20639863.
#"Topics" page open. (2010.10.18)
#”Expression Information” page open. (2010.06.02) X-gal staining was performed for detecting beta-galactosidase reporter expression in a wide variety of adult tissues of the Ayu21-W6 mouse line.
#(Publication/IGTC & EGTC) "International Gene Trap Project: Towards Gene-driven Saturation Mutagenesis in Mice." M. Araki, et al., Current Pharmaceutical Biotechnology, 10, 221-229 (2009). PubMed ID: 19199955.
#EGTC database renewal. (2009.10.03)
#(Publication/Ayu21-127) "Defective development of the gall bladder and cystic duct in Lgr4- hypomorphic mice." R. Yamashita, et al., Dev. Dyn., 238, 993-1000 (2009). doi: 10.1002/dvdy.21900. PubMed ID: 19301403.
#(Publication/Ayu21-18) "Basonuclin 2 has a function in the multiplication of embryonic craniofacial mesenchymal cells and is orthologous to disco proteins." A. Vanhoutteghem, et al., Proc. Natl. Acad. Sci. USA, 106, 14432-14437 (2009). PubMed ID: 19706529.
#(Publication/Ayu21-127) "LGR4 regulates the postnatal development and integrity of male reproductive tracts in mice." T. Hoshii, et al., Biol. Reprod., 76, 303-313 (2007). PubMed ID: 17079737.